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We report that the transcription factor SOX5 controls the sequential generation of distinct corticofugal neuron subtypes by preventing premature emergence of normally later-born corticofugal neurons.
SOX5 loss-of-function causes striking overlap of the identities of the three principal sequentially born corticofugal neuron subtypes: subplate neurons, corticothalamic neurons, and subcerebral projection neurons.
In cortex, subplate neurons aberrantly develop molecular hallmarks and connectivity of subcerebral projection neurons; corticothalamic neurons are imprecisely differentiated, while differentiation of subcerebral projection neurons is accelerated.
Active spice-derived components can inhibit inflammatory responses of adipose tissue in obesity by suppressing inflammatory actions of macrophages and release of monocyte chemoattractant protein-1 from adipocytes.The cat FISH (cellular Compartment Analysis of Temporal activity by Fluorescence In Situ Hybridization) method allows us to trace back when a specific neuron has been activated.By using labeling for the RNA of the immediate early gene (IEG) zif268 for example, we know that when we detect its RNA in 2 punctae in the nucleus, zif268 gene transcription was initiated 5min ago.Effect of allyl isothiocyanate (AITC) in both nitrite- and nitrosamine-induced cell death, production of reactive oxygen species, and DNA damage by the single-cell gel electrophoresis (SCGE): does it have any protective effect on Hep G2 cells?Glutathione S-transferase subunit induction patterns of Brussels sprouts, allyl isothiocyanate and goitrin in rat liver and small intestinal mucosa: a new approach for the identification of inducing xenobiotics.[Antibiotic effect of the allyl isothiocyanate extracted from various horticultural forms of the seeds of Raphanus Sativus L., var. towards various bacteria, including two strains of tubercle bacillus avian type, Cow 18 and Cow 70; Note II].